Pyridine, 2-chloro-3-fluoro-4-(trifluoromethyl)-
2-Chloro-3-fluoro-4-(trifluoromethyl)pyridine
CAS: 628692-22-8
Molecular Formula: C6H2ClF4N
Pyridine, 2-chloro-3-fluoro-4-(trifluoromethyl)- - Names and Identifiers
| Name | 2-Chloro-3-fluoro-4-(trifluoromethyl)pyridine |
| Synonyms | T6NJ BG CF DXFFF [WLN] 2-Chloro-3-fluoro-4-(trifluoromethyl)pyridine 2-CHLORO-3-FLUORO-4-(TRIFLUOROMETHYL)PYRIDINE Pyridine, 2-chloro-3-fluoro-4-(trifluoromethyl)- |
| CAS | 628692-22-8 |
| EINECS | 672-531-1 |
| InChI | InChI=1/C6H2ClF4N/c7-5-4(8)3(1-2-12-5)6(9,10)11/h1-2H |
Pyridine, 2-chloro-3-fluoro-4-(trifluoromethyl)- - Physico-chemical Properties
| Molecular Formula | C6H2ClF4N |
| Molar Mass | 199.53 |
| Density | 1.506 g/mL at 25 °C |
| Boling Point | 35-37°C 25mm |
| Flash Point | 35-37°C/25mm |
| Vapor Presure | 1.78mmHg at 25°C |
| pKa | -1.53±0.10(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| Refractive Index | 1.44 |
Pyridine, 2-chloro-3-fluoro-4-(trifluoromethyl)- - Risk and Safety
| Risk Codes | R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin. R25 - Toxic if swallowed |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37 - Wear suitable protective clothing and gloves. S9 - Keep container in a well-ventilated place. |
| UN IDs | 2810 |
| WGK Germany | 3 |
| HS Code | 29333990 |
| Hazard Note | Irritant |
| Hazard Class | 6.1 |
| Packing Group | III |
Pyridine, 2-chloro-3-fluoro-4-(trifluoromethyl)- - Introduction
2-Chloro-3-fluoro-4-(trifluoromethyl)pyridine is an organic compound with the chemical formula C6H2ClF4N. The following is a description of its nature, use, preparation and safety information:
Nature:
-Appearance: Colorless liquid or solid
-Boiling point: about 160-162°C
-Density: 1.64 g/mL
-relative molecular mass: 201.54g/mol
-Solubility: Soluble in alcohol and ether solvents, slightly soluble in water
Use:
- 2-Chloro-3-fluoro-4-(trifluoromethyl)pyridine is a compound widely used in organic synthesis and is often used as an intermediate in organic synthesis.
-It can be used to prepare organic compounds such as medicines, pesticides, dyes, etc.
-Due to its unique chemical properties, it can also be used in the fields of catalysts, solvents and surfactants.
Preparation Method:
A commonly used preparation method is to synthesize 2-Chloro-3-fluoro-4-(trifluoromethyl)pyridine through the fluorine and chlorine substitution reaction of pyridine. Specific steps are as follows:
1. pyridine is reacted with boron trifluoride (BF3) in methyl chloride (CH2Cl2) to generate 3-fluoropyridine.
2. 3-fluoropyridine reacts with liquid chlorine and hydrofluoric acid (HF) to generate 2-chloro-3-fluoropyridine.
3. Finally, 2-chloro-3-fluoropyridine was reacted with sodium trifluoromethylfluoride (NaF.3CF3) to give 2-Chloro-3-fluoro-4-(trifluoromethyl)pyridine.
Safety Information:
- 2-Chloro-3-fluoro-4-(trifluoromethyl)pyridine is an organic compound that may be irritating to the skin, eyes, and respiratory tract.
-When using it should wear appropriate protective measures, such as wear protective gloves, goggles and protective mask, and ensure that the operation in a well-ventilated environment.
-This compound should be kept away from fire and oxidizing agents, and kept sealed.
-Before use, you should understand and follow the relevant safety procedures and use recommendations in detail.
Nature:
-Appearance: Colorless liquid or solid
-Boiling point: about 160-162°C
-Density: 1.64 g/mL
-relative molecular mass: 201.54g/mol
-Solubility: Soluble in alcohol and ether solvents, slightly soluble in water
Use:
- 2-Chloro-3-fluoro-4-(trifluoromethyl)pyridine is a compound widely used in organic synthesis and is often used as an intermediate in organic synthesis.
-It can be used to prepare organic compounds such as medicines, pesticides, dyes, etc.
-Due to its unique chemical properties, it can also be used in the fields of catalysts, solvents and surfactants.
Preparation Method:
A commonly used preparation method is to synthesize 2-Chloro-3-fluoro-4-(trifluoromethyl)pyridine through the fluorine and chlorine substitution reaction of pyridine. Specific steps are as follows:
1. pyridine is reacted with boron trifluoride (BF3) in methyl chloride (CH2Cl2) to generate 3-fluoropyridine.
2. 3-fluoropyridine reacts with liquid chlorine and hydrofluoric acid (HF) to generate 2-chloro-3-fluoropyridine.
3. Finally, 2-chloro-3-fluoropyridine was reacted with sodium trifluoromethylfluoride (NaF.3CF3) to give 2-Chloro-3-fluoro-4-(trifluoromethyl)pyridine.
Safety Information:
- 2-Chloro-3-fluoro-4-(trifluoromethyl)pyridine is an organic compound that may be irritating to the skin, eyes, and respiratory tract.
-When using it should wear appropriate protective measures, such as wear protective gloves, goggles and protective mask, and ensure that the operation in a well-ventilated environment.
-This compound should be kept away from fire and oxidizing agents, and kept sealed.
-Before use, you should understand and follow the relevant safety procedures and use recommendations in detail.
Last Update：2024-04-09 21:04:16
